A parking garage has no single standard size in the United States. Its footprint and capacity depend on the site, parking angle, drive aisles, ramp arrangement, columns and walls, accessible spaces, pedestrian routes, stairs, elevators, fire access, and local requirements.
A useful way to estimate a basic layout is to start with one parking module. In a 90-degree, double-loaded layout, vehicles park on both sides of a central drive aisle. San Diego County's parking regulations list standard stalls at 9 × 18 feet and a 26-foot two-way aisle for 90-degree parking. Its corresponding two-way module width is 62 feet, which accounts for two stall depths and the aisle.
Illustrative module arithmetic: ten stalls arranged as five on each side of the aisle occupy about 45 feet along the row (5 × 9 feet). At 62 feet deep, the simple module is about 2,790 square feet (45 × 62). This is only the parking module. It leaves out columns, perimeter walls, ramps, accessible-space configurations, elevators, stairs, service rooms, and other circulation or code requirements.
See the San Diego County off-street parking design standards for that jurisdiction's table and rules. An open parking lot layout guide covers surface parking.