Five pounds of human adipose tissue would occupy roughly 2.47 liters (about 0.65 U.S. gallon) using one published tissue-density reference. Twenty pounds would be about 9.86 liters (2.61 gallons). These are estimates for isolated tissue volume, not a prediction of how a change in body weight looks on a person.
The calculation uses an adipose-tissue density of 0.9196 kg/L reported in a study of body-fat compartments. Tissue composition varies, so treat the result as a visual reference rather than an exact universal volume.